Stephen Back Profile Page
Stephen Back

Profile

Stephen
Back
...
Pomona College
B.A.
UCI
MD, PHD

Research

Charles Gorenstein
Fluorescent Immunohistochemical Localization of Neutral endopeptidase 24.11 (Enkephalinase) in the rat brain
Neuroscience, Developmental Biology, Medical Imaging
Peer-reviewed
1. Roberts, D.C.S., W.J. Shoemaker, S.A. Back, F.E Bloom. Modulation of 3H-dihydroalprenolol binding in the hippocampus by corticosterone. In: Steroid Hormone Regulation of the Brain (Fuxe, K., Gustafson, J-A., and Wetterberg, L., eds.) pp. 379-384, Pergamon Press, Oxford (1981).
2. Back, S.A., J.A. Alhadef. Characterization of α2-macroglobulin from plasma of cystic fibrosis patients and controls. Biochemical Medicine 30:34-42 (1983).
3. Back, S.A., J.A. Alhadef. Differential isoelectric focusing properties of crude and purified human α2-macroglobulin and α2-macroglobulin-proteases complexes. Journal of Chromatography 278:43-51 (1983).
4. Back, S.A., M. Lorenzi, J.A Alhadeff. J.A. Altered isoelectric focusing properties of α2-macroglobulin from plasma of patients with diabetes mellitus. Clinica Chimica Acta 150:21-29 (1985).
5. Back, S.A., C. Gorenstein. Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the rat spinal cord. Journal of Comparative Neurology 280(3):436-450 (1989).
6. Back, S.A., C. Gorenstein. Histochemical Visualization of Neutral Endopeptidase-24.11 (Enkephalinase) Activity in Rat Brain: Cellular Localization and Codistribution with Enkephalin in the Globus Pallidus. Journal of Neuroscience 9:4439-4455 (1989).
7. Back, S.A., C. Gorenstein. Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the brainstem of the rat. Journal of Comparative Neurology 296:130-158 (1990).
8. Mason, P., Back, S.A., H.L. Fields. Enkephalin immunoreactive contacts onto physiologically identified on-cells in the rat rostral ventromedial medulla. Journal of Neuroscience 12 (10):4023-4036 (1992).
9. Back, S.A., J.A. Alhadeff. Differential isoelectric focusing properties of α2-macroglobulin from plasma of patients with chronic progressive or relapsing-remitting multiple sclerosis. Clinica Chimica Acta 211:27-36 (1992).
10. Back, S.A., M. Colon, J.H. Fallon, F.L. Meyskens, S. Loughlin. Ventral mesencephalic and cortical transplants into the rat striatum display enhanced activity for neutral endopeptidase 24.11 ("enkephalinase"; CALLA), Brain Research 612(1):78-88 (1993).
11. Back, S.A., C. Gorenstein. Differential response of neutral endopeptidase 24.11 (enkephalinase), cholinergic and opiodergic markers to hypoglossal axotomy. Journal of Comparative Neurology 340:149-160 (1994).
12. Yonezawa, M., S.A. Back, X. Gan, P.A. Rosenberg, J.J. Volpe. Cysteine deprivation induces oligodendroglial death: rescue by free radical scavengers and by a diffusible glial factor. Journal of Neurochemistry 67:566-573 (1996).
13. Back, S.A., X. Gan, Y. LI, P.A. Rosenberg, J.J. Volpe. Maturation-dependent vulnerability of oligodendroctyes to oxidative stress-induced death caused by glutathione depletion. Journal of Neuroscience 18(16):6241-6253 (1998).
14. Rosenberg, P.A., Y. Li, S. Ali, N.A., Altiok, S.A. Back, J.J. Volpe. Intracellular redox state determines whether nitric oxide is toxic or protective to rat oligodendrocytes in culture. Journal of Neurochemistry 73:476-48 (1999).
15. Back, S.A., R. Kahn, X. Gan, P.A. Rosenberg, J.J. Volpe. A new Alamar Blue viability assay to rapidly quantify oligodendrocyte death. Journal of Neuroscience Methods 9:47-54 (1999).
16. Hee-Han, B., A. D. Costa, S.A. Back, M Parsadanian, S Patel, A.R. Shah, J.M. Gidday, A. Srinivasan, M. Deshmukh and D.M.Holtzman. BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia. Neurobiology of Disease 7:38-53 (2000).
17. Back, S.A., N.L. Luo, N.S. Borenstein, J.M. Levine, J.J. Volpe, H.C. Kinney. Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury. Journal of Neuroscience 22(4):1302-1312 (2001).
18. Back, S.A., B. Hee-Han, N.L. Luo, C.A. Chricton, S. Xanthoudakis, J. Tam, K.L. Arvin, D.M. Holtzman. Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia. Journal of Neuroscience 22(2): 453-463 (2002).
19. Back, S.A., N.L. Luo, N.S. Borenstein, J.J. Volpe, H.C. Kinney. Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelination. Journal of Neuropathology and Experimental Neurology 61(3):197-211 (2002).
20. Rosenberg, P.A., D. Weimin, X.D. Gan, S. Ali, J. Fu, S.A. Back, R.M. Sanchez, M.M. Segal, P.L. Follet, F.E. Jensen, J.J. Volpe. Mature myelin basic protein expressing oligodendrocytes are insensitive to kainate toxicity. Journal of Neuroscience Research 71(2):237-245 (2003).
21. Craig, A., N.L. Luo, D.J. Beardsley, N. Wingate-Pearse, D.W. Walker, A.R. Hohimer, S.A. Back. Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human. Experimental Neurology 181(2):115-333. (2003).
22. Derrick, M., N.L. Luo, J.C., Bregman, T. Jilling, X. Ji, K. Fisher, C.L. Gladson, D.J. Beardsley, G.H. Murdoch, S.A. Back*, S. Tan* (*Joint senior authors). Preterm fetal hypoxia causes hypertonia and motor deficits in the neonatal rabbit: a model for human cerebral palsy? Journal of Neuroscience 24(1):24-34, 2004.
23. Han, S.S., Wu Y., Tuohy, T.M., Xue, H., Cai J., Back S.A., Sherman L.S., Fischer I., Rao M.S. (2004) CD44 expression identifies astrocyte restricted precursor cells. Developmental Biology, 276:31-46 (2004).
24. Kisby, G.E., M. Standley, X. Lu, J. O'Malley, B. Lin, J. Muniz, N.L. Luo, P. Pattee, S.A. Back, S.R. Nagalla. Molecular networks perturbed in a developmental model of brain injury. Neurobiology of Disease 19:108-118 (2005).
25. Back, S.A., N.L. Luo N.L., R.A. Mallinson, J.P. O'Malley, L.D. Wallen, B. Frei, J.D. Morrow, C.K. Petito, C.T. Roberts Jr., G.H. Murdoch, T.J. Montine. Human preterm cerebral white matter is selectively vulnerable to oxidative damage identified by F2-isoprostanes, Annals of Neurology 58:108-120, 2005.
26. Drobyshevsky, A, S.-K.Song, G. Gamkrelidze, A. M. Wyrwicz, M. Derrick, F. Meng, L. Li, X. Ji, B. Trommer, D. J.Beardsley, N.L. Luo, S.A. Back*, S. Tan* (*Joint senior authors). Developmental changes in diffusion anisotropy coincide with immature oligodendrocyte progression and maturation of compound action potential, Journal of Neuroscience, 25:5988-5997, 2005.
27. Back, S.A., Tuohy, T.M.F., H. Chen, N. Wallingford, A. Craig, J. Struve, N.L. Luo, F. Banine, Y. Liu, A. Chang, B.D. Trapp, B.F. Bebo, Jr., M.S. Rao, L.S. Sherman. Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation, Nature Medicine, 9:966-972, 2005.
28. Riddle, A., N.L. Luo, M. Manese, D.J. Beardsley, L. Green, D.A. Rorvik,, K.A. Kelly, C.H. Barlow, C.J. Kelly, A.R. Hohimer, S.A. Back. Spatial heterogeneity in oligodendrocyte maturation and not cerebral blood flow predicts fetal ovine periventricular white matter injury, Journal of Neuroscience, 26:3045-3055, 2006.
29. Back, S.A., A. Riddle, A.R. Hohimer, Role of fetal sheep preparations in defining the pathogenesis of human periventricualr white matter injury, Journal of Child Neurology,21:582-589, 2006.
30. Back, S.A., A. Craig, R. Kayton, N.L. Luo, C.K. Meshul, N. Allcock, R. Fern. Hypoxia-ischemia preferentially triggers glutamate depletion from oligodendroglia and axons in perinatal cerebral white matter. Journal of Cerebral Blood Flow and Metabolism 27:334-347 (2007).
31. Back, S.A., A. Craig, N.L. Luo, J. Ren, R.S. Akundi, I. Ribeiro, S.A. Rivkees. Protective effects of caffeine on chronic hypoxia-induced cerebral white matter injury, Annals of Neurology, 60:696-705 (2006).
32. Broughton, S.K., H. Chen, A. Riddle, S. Kuhn, S. Nagalla, C.T. Roberts Jr., S.A. Back. Large-scale generation of highly enriched neural stem cell-derived oligodendroglial cultures: Maturation-dependent differences in insulin-like growth factor-mediated signal transduction, Journal of Neurochemistry, 100:628-638 (2007).
33. McClure, M., A. Riddle, M. Manese, N.L. Luo, D.A. Rorvik, K.A.Kelly, C.H. Barlow, J.J. Kelly, K. Vinecore, C. Roberts, A. Roger Hohimer, S.A. Back. Cerebral blood flow heterogeneity in preterm sheep: lack of physiological support for vascular boundary zones in fetal cerebral white matter, Journal of Cerebral Blood Flow and Metabolism, 28(5):995-1008 (2008).
34. Segovia, K.N., M.M. Mcclure, M. Moravec, N.L. Luo, Y. Wan, X. Gong, A. Riddle, A. Craig, J. Struve, L.S. Sherman and S.A. Back. Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury, Annals of Neurology, 63(4):517-526 (2008).
35. Buser J.R., K.N. Segovia, J.M. Dean, K. Nelson, D. Beardsley, X. Gong, N. L. Luo, J. Ren, Y. Wan, A. Riddle, M.M. McClure, X. Ji, M. Derrick, A. R. Hohimer, S. A. Back*, S. Tan* (*Joint senior authors). Timing of appearance of late oligodendrocyte progenitors coincides with enhanced susceptibility of preterm rabbit cerebral white matter to hypoxia-ischemia, Journal of Cerebral Blood Flow and Metabolism, 30(5):1053-1065 (2010).
36. Dean J.M., Moravec M.D., Grafe M.R., Abend N., Ren J., Gong X., Volpe J.J., Jensen F.E,, Hohimer A.R. and S.A. Back (2011) Strain-specific differences in perinatal rodent oligodendrocyte lineage progression and its correlation with human, Developmental Neuroscience, 33(3-4):251-260.
37. Lodygensky, G.A., T. West, M. Moravec, S.A. Back, K. Dikranien, D.M. Holtzman and J.J. Neil (2011) “Diffusion characteristics associated with neuronal injury and glial activation following hypoxia-ischemia in the immature brain, Magnetic Resonance in Medicine, 66 (3): 839-845.
38. Back, S.A., Kroenke C, Sherman, L.S., Lawrence G., Gong X., Taber E.N., Sonnen J.A., Larson E.B. and T.J. Montine (2011). White matter lesions defined by diffusion tensor imaging in older adults, Annals of Neurology, 70(3): 465-476.
39. Riddle, A., Dean J.M, Buser, J.R., Gong X., Maire J., Chen K., Ahmad T., Chen V., Nguyen T., Kroenke C.D., Hohimer A.R. and S.A. Back (2011) Histopathological correlates of MRI-defined chronic perinatal white matter injury, Annals of Neurology, 70(3): 493-507 (2011).
40. Cargill R., S. G. Kohama, J. Struve, W. Su, F. Banine, E. Witkowski, S.A. Back and L. S. Sherman. Reactive astrocytes in aged primate gray matter synthesize excess hyaluronan linked to oligodendrocyte progenitor accumulation, Neurobiology of Aging, in press.
41. Dean J., Riddle A., Maire, J., Hansen, K.D., Preston, M., Barnes, A.P. and S.A. Back (2011). An organotypic slice culture model of chronic white matter injury with maturation arrest of oligodendrocyte progenitors. Molecular Neurodegeneration, Jul 5;6:46.
42. Riddle, A., Maire, J. Gong, X., Chen, K.X., Kroenke, C.D., Hohimer, A.R., and S.A. Back. Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter injury. Stroke, 43(1):178-184 (2012).
43. Buser, J.R., Maire, J., Riddle, A., Nelson, K., Gong, X., Luo, N.L., Ren, J., Nguyen, T., Struve, J., Sherman, L.S., Miller, S.P., Chau, V., Hendson, G., Ballabh, P. Grafe, M.R. and S.A. Back, Myelination failure in human perinatal white matter injury: Arrested pre-oligodendrocyye maturation contributes to myelination failure in premature infants. Annals of Neurology, 71(1): 93-109 (2012).
44. Uchida, N., Chen K., Hansen, K.D., Buser, J.R., Gong, X., Riddle A. R., Dean, J.M., Wan, Y., Beardsley, D.J., Cummings, B.J., Anderson, A.J., Matsumoto, S., Sherman, L.S., Dohse, M., Tamaki, S.J., S.A.Back. Human neural stem cells preferentially generate oligodendrocytes equipotent for functional myelination of neonatal and juvenile cerebral white matter, Science Translational Medicine, 4(155):155ra136.
45. Brambrink, A.M., S.A. Back, A. Riddle, X. Gong, M. Moravec, A.S. Evers, M.S. Avidan, N. Farber, G.A. Nissen, C.E. Creeley, J.W. Olney. Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain, Annals of Neurology, 72 (4):525-535, 2012.
46. Alix, J.J.P., C. Zammit, A. Riddle, C.K. Meshul, S.A. Back, M. Valentino, R. Fern. Central axons preparing to myelinate are highly sensitivity to ischemic injury due to the transient expression of Ca2+ channels, Annals of Neurology, in press.
47. M. Preston, X. Gong, W. Su, F. Banine, C. Winkler, S. Foster, R. Xing, J. Struve, J. Dean, T.J. Montine, S.A. Back and L.S. Sherman, Digestion products of the PH20 hyaluronidase inhibit remyelination, Annals of Neurology, in press.
48. Dean, J.M., E. McClendon, K. Hansen, A. Azimi-Zonooz, K. Chen, A. Riddle, X. Gong, E. Sharifnia, M. Hagen, T. Ahmad, L.A. Leigland, A.R. Hohimer, C.D. Kroenke, S. A. Back. Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure via disturbances in neuronal arborization, Science Translational Medicine, in press.

Book Chapters and Reviews
1. Back, S.A., J.J. Volpe. Cellular and molecular pathogenesis of periventricular leukomalacia. Mental Retardation and Developmental Disabilities Research Reviews 3(1):96-107 (1997).
2. Kinney, H.C. and S.A. Back. Human oligodendroglial development: relationship to periventricular leukomalacia. In: Seminars in Pediatric Neurology 5(3):180-189 (1998)..
3. Back, S.A., J.J. Volpe. Approaches to the study of diseases of oligodendrocyte death. In: Cell Death and Diseases of the Nervous System (Koliatsos, V. and Ratan, R.R., eds.) Academic Press, New York, pp. 401-427 (1999).
4. Back, S.A. Cerebral Palsy, In: Developmental-Behavioral Pediatrics, 3rd edition, (Levine, M.D., Carey, W.B. and Crocker, A.C., eds.), Saunders, Philadelphia, pp. 579-588 (1999).
5. Back, S.A. Recent advances in human perinatal white matter injury. Progress in Brain Research 132:131-147 (B Castellano and M Nieto-Samapredro, eds.), Elsevier, Amsterdam (2001).
6. Back, S.A. Approaches to the cellular and molecular pathogenesis of human perinatal white matter injury. In: Cerebrovascular disease: Momentum at the end of the second millenium (21st Princeton Conference) (DW Choi, RG Dacey Jr, CH Hsu, WJ Powers,eds), Futura Press, Armonk, New York, pp.131-160 (2001).
7. Gleason, C.A. and S.A. Back, Developmental physiology of the central nervous system system, In: Avery's Diseases of the Newborn, 8 th edition (Teusch, WR, Ballard R.A., Gleason, C.A.) Saunders, Philadelphia, pp. 903-907 (2004).
8. Back, S.A. Congenital malformations of the central nervous system development, In: Avery's Diseases of the Newborn, 8 th edition (Teusch, WR, Ballard R.A., Gleason, C.A.) Saunders, Philadelphia, pp. 938-963 (2004).
9. Rivkees, SA and S.A. Back. Emerging concepts in perinatal white matter injury, Seminars in Perinatology, 28:405-414 (2004).
10. Back, S.A. Perinatal White Matter Injury: The changing spectrum of pathology and emerging insights into pathogenetic mechanisms. Mental Retardation and Developmental Disabilities Research Reviews, 12(2):129-140 (2006).
11. Back, S.A., A. Riddle and M. McClure (2007) Maturation-dependent vulnerability of perinatal white matter in premature birth. Stroke, 38:724-730.
12. Back, S.A. and S.P. Miller (2007) Can We Explain the Changing Spectrum of Cerebral White Matter Injury in survivors of preterm birth? NeoReviews.
13. Sherman, L.S. and S.A. Back (2008) A GAG reflex prevents repair of the damaged CNS. Trends in Neuroscience, 31:44-52.
14. Gleason, C.A. A.R. Hohimer, and S.A. Back, Developmental physiology of the central nervous system system, In: Avery's Diseases of the Newborn, 9 th edition (Gleason, C.A., Devaskar, S.U.) Saunders, Philadelphia pp. 811-815, 2012.
15. Back, S.A. and L.L. Plawner Congenital malformations of the central nervous system development, In: Avery's Diseases of the Newborn, 9 th edition (Gleason, C.A., Devaskar, S.U.) Saunders, Philadelphia, pp. 844-868, 2012.
16. Silbereis J.C., Huang E.J., Back S.A., Rowitch D.H. (2010) Towards improved animal models of neonatal white matter injury associated with cerebral palsy. Dis Model Mech. 2010 3(11-12):678-88.
17. Back, S.A. (2011) Mechanisms of Acute and Chronic Brain Injury in the Preterm Infant. In: Acquired Brain Injury, (Miller, S.P. and Shevell M., eds.), International Reviews in Child Neurology (IRCN), McKeith Press, London, in press.
18. Back, S.A., Riddle, A.R., Hohimer, A.R. (2011) The Sheep as a Model of White Matter Injury in the Preterm Infant. In: Animal Models Neurodevelopmental Disorders, Neuromethods Series; (Wolz, W, and Yager, J., Ed.) Humana Press, Springer, in press.
19. Back, S.A., Riddle, A.R., Hohimer, A.R. (2012) The instrumented fetal sheep as a model of cerebral white matter injury in the preterm infant. In: Neurotherapeutics, Special Issue: Animal Models of Neurological Disorders (Carmichael, S.T. and Chesselet, M.F. eds.), Neurotherapeutics 9(2):359-70, 2012.
20. Bennet, L, Tan S., Van den Heuij, L., Derrick M., Groenendaal, F., van Bel, F., Juul, S., Back, S.A., Northington, F., Robertson, N.J., Mallard, C., Gunn A.J. Cell therapy for Neonatal Hypoxia-Ischemia and Cerebral Palsy, Annals of Neurology 71(5):589-600, 2012.
21. Robertson, N.J., Tan, S., Groenendaal, F., van Bel, F., Juul, S., Bennett, L., Derrick M., Back, S.A., Valdez, R.C., Northington, F., Barks, J., Cai, Z., Gunn, A.J., Mallard, C. Which neuroprotective agents are ready for bench to bedside translation in the newborn infant? Journal of Pediatrics 160(4):544-552, 2012.
Invited Conferences, Symposia and Workshops:
International and National (1998-2012)

21st Princeton Conference on Cerebrovascular Disease, Saint Louis, MO, 5/08/98
Symposium on: White matter ischemia-Unique mechanisms of injury?
"Oligodendrocyte death in the developing brain"

IVth European Meeting on Glial Cell Function, Barcelon, Spain, 5/24/00
Symposium on "Injury mechanisms operating in glia during the acute phase of ischemia"
"Ischemia and oligodendrocytes in vivo"

29th Annual Meeting of the Child Neurology Society, Saint Louis, 10/26/00
Young Investigator Award Lecture for 2000

2001
Sam Hersch Cerebral Palsy Symposium, The Salk Institute, La Jolla, CA 2/27/01
"Human oligodendroglial progenitors as vulnerable targets in periventricular leukomalacia"

Western Society for Pediatric Research, Caramel, CA State of the Art Lecture, 2/01
"Pathogenesis of cerebral white matter injury in the premature infant"

2002
Third Hershey Conference on Developmental Cerebral Blood Blow and Metabolism, Hershey, PA, 6/07/02
Symposium on "White Matter Injury"
"Hypoxia-ischemia and oligodendrocyte death in the developing brain"

2003
28th International Stroke Conference of the American Heart Association: Symposium on "Ischemia and Stroke in the Very Young", Phoenix, AZ , 2/12/03
"White matter injury in the young"

XXIst Meeting of the International Society for Cerebral Blood Flow and Metabolism, Calgary, Canada, 7/03/03.
Symposium on "Hypoxic-Ischemic Damage in Developing White Matter"
"Vulnerability of developing cerebral white matter to hypoxia ischemia"

2004
Workshop on Experimental Models of Cerebral Palsy, sponsored by the United Cerebral Palsy Research Foundation, Asilomar, CA 6/14/04
"Experimental models of human cerebral white matter injury",

2005
Nancy Davis Centers Meeting on Recent Advances in Multiple Sclerosis Research, Los Angeles, CA, 4/22/05
"Susceptibility of oligodendrocyte progenitors to oxidative stress"

American Academy of Cerebral Palsy Annual Meeting, Orlando, Florida, 9/05
Mac Keith Basic Science Lecturer: Emerging concepts in the pathogenesis of cerebral palsy in survivors of premature birth.

2006
Workshop on "Neurotrophic Factors as Therapeutic Treatments for Pediatric Neurological Disorders: Moving the Field Forward," San Jose California, 2/28-3/3/06.
Sponsors: Children's Neurobiological Solutions and AT Children's Project
"Overview of hypoxic-ischemic injury to the developing brain"

American Society of Neurochemistry 37th Annual Meeting, Portland, Oregon, March 11, 2006
Public Forum: New Directions in Stroke Prevention and Treatment for Children and Adults (Symposium Organizer)
“Stroke and ischemic brain injury in infants and children”

American Society of Neurochemistry, 37th Annual Meeting, Portland, Oregon, March 15, 2006
Symposium on “Role of the Neurovascular Unit in Neurological Disease (Symposium Organizer)
"Maturation-dependent mechanisms of vulnerability of ischemic perinatal white matter injury"

Scientific Symposium on Perinatal Brain Injury in Honor of Dr. Joseph J. Volpe, Boston Children’s Hospital, May 5, 2006.
“Perinatal White matter injury: a new experimental model of preterm hypoxia-ischemia in fetal sheep relevant to pathogenesis and prevention.”

25th Princeton Conference on Cerebrovascular Disease, Portland, Oregon, May 18-20, 2006 Symposium on Cerebral Ischemia and the Developing Brain (Symposium Organizer)
"Maturation-dependent vulnerability in brain”

NINDS Workshop on Vascular Cognitive Dementia, June 1-2, 2006, Washington, D.C.
"Cellular mechanisms of ischemic cerebral white matter injury"

31st Annual Conference on Neonatal/Perinatal Medicine, American Academy of Pediatrics, Girdwood, Alaska, 6/29/06-7/02/06.
“Timing is everything: How does brain development predispose to unique patterns of brain injury and cerebral palsy after premature birth?”

Visiting Professorship coordinated with Australian National Cerebral Palsy Awareness Week, August 6-13, 2006. Included lectures, radio, newspaper, and television interviews in Sydney, Melbourne and Adelaide to promote Australian public awareness of the pressing need for research in cerebral palsy. Organizing Host: Spastic Centre, Sydney Australia.

Presidential Symposium on Cerebral Palsy, Annual Meeting of the Child Neurology Society, 10/19/06
“Cellular-molecular pathogenesis of cerebral palsy”

Children’s Hospital of Fudan University, Shanghai, China, Visiting Professor, 11/28/06-11/30/06.
Two lectures in translation to Pediatric Faculty and Pediatric Graduate students.

Wenzhou Medical College International Pediatric Forum, Wenzhou, China and Visiting Professor at Yuying Children’s Hospital and Wenzhou Medical College, 11/30/06-12/3/06. Two lectures in translation to Pediatric Faculty and Pediatric Graduate students.

West China Second University Hospital and West China Women’s and Children’s Hospital, Sichuan University, Chengdu, China, 12/05/06-12/8/06, Two lectures in translation to Pediatric Faculty and Pediatric Graduate students.

2007
Pfizer Visiting Professorship in Neurology, University of California, Irvine, Department of Pediatrics, March 27-30, 2007. Supported by a $7500.00 award (one of eight awarded nationally for 2006-2007).

2008
Australian Neuroscience Society Annual Meeting, Hobart, Tasmania, 1/28/08
Symposium on: “Perinatal brain injury: targeting mechanisms to achieve functional improvement”
“Pathogenesis of Periventricular white matter injury: (PWMI): have we been thinking about this all wrong?”

NIH Course: 2nd Annual Symposium on “Stem Cell Therapies for Pediatric Diseases and Injuries: A Critical Evaluation, ” Children’s Hospital of Orange County, 3/18/08
“Brain barriers to stem cell neurotherapy”

Newborn Brain Symposium (9/10-9/13/08) Children’s Hospital-St. Louis, Washington University
“Mechanisms of Injury in the Preterm Brain”

Neurobiology of Disease in Children: Injury to the Preterm Brain and Cerebral Palsy; NIH-supported Satellite Symposium of the 37th Annual Meeting of the Child Neurology Society, Santa Clara, CA, 11/05/08
“Experimental models of white matter injury”

37th Annual Meeting of the Child Neurology Society, Santa Clara, CA, 11/08/08.
Breakfast symposium Organizer and Moderator:
“The first human neural stem cell trial: Rationale, Insights and Future Directions”

2009
NINDS Strategic Planning Final Meeting: Working Group 1; Disease Modules (1/14/09); Rockville, Maryland

2nd Shanghai Neonatal Forum; Children’s Hospital of Fudan University, April 9-11. 2009
Pre-Symposium Session on Animal Models of Perinatal Brain Injury (4/8/09)
“Rodent Models of White Matter Injury”
Session 1: Cerebral white matter injury in preterm survivors: New insights into pathogenesis and prevention.

Northwest Pediatric Neurology Colloquium, June 5, 2009
Children’s and Women’s Hospital, Univeristy of British Columbia, Vancouver, Canada
“Cerebral white matter injury in preterm survivors: New insights into pathogenesis and prevention”

9th European Meeting on Glial Cells in Health and Disease, Paris France (September 8-12, 2009)
Symposium Organizer and Presenter:
“Mechanisms of Death and Regeneration of Oligodendroglial Progenitors in White Matter Injury”
Presentation #4: “Mechanisms of OPC Plasticity in Animal Models of Chronic White Matter Injury”

2011
Pediatric Academic Societies Meeting, Denver, Colorada (April 30-May 3, 2011)
PAS Topic Symposium: Novel Mechanisms of Perinatal Brain Injury
Speaker #1: Cellular and molecular mechanisms of white matter injury in human preterm infants

NINDS Workshop on Therapy Development for Diffuse Axonal Injury, Rockville, Maryland (May 17-18, 2011)
Session V: New Approaches and Tools Available for Therapy Development for Diffuse Axonal Injury
Presentation: “High field MRI for preclinical studies”

California Institute for Regenerative Medicine
Workshop on Newborn Neurological Disorders Leading to Cerebral Palsy, San Francisco, CA (June 8-9, 2011)
Session 1: Clinical Features, Current Concepts and Research
Presentation: Common Terminology Used in the CP Community
Presentation: Applications of high field MRI to define preterm white matter injury
Presentation: Neuropathology of brain injury in the premature infant

10th European Meeting on Glial Cells in Health and Disease, Prague, Czech Republic (September 13-17. 2011)
Symposium Organizer and Presenter:
“The influence of glycosaminoglycans on glia and neural progenitors”
Presentation #2: “Role of hyaluronan in the injured perinatal and elderly brain”

2012
Oregon Chapter, Society for Neuroscience, Annual Meeting, Troutdale, Oregon, April 6-7, 2012,
“Perinatal white matter injury: unexpected mechanisms of regeneration and repair”

Pediatric Academic Societies Meeting, Boston, MA (April 28-May 1, 2012)
PAS Topic Symposium: New Insights into the Neuropathology of Neonatal White Matter Injury: Implications for Understanding Pathogenesis, Clinical and Imaging Correlates, and Potential Therapeutic Targets
Speaker #4: Potential Therapeutic Targets Identified in Animal Models of White Matter Injury

Eighth Hershey Conference on Developmental Cerebral Blood Blow and Metabolism, London, UK, 6/07/12
Connectivity in normal and abnormal development "Chronic disturbances in cortical neuronal arborization following global fetal cerebral ischemia”

Opportunities for Hydrocephalus Research: Pathways to Better Outcomes, Seattle, Washington, July 9-11, 2012
Plenary Session 2 (Pathophysiological Modifications): “Mechanisms and potential therapies of white matter injury: unexpected mechanisms of regeneration and repair”

2012 VIsiting Professorships

Department of Pediatrics, Division of Neonatal Medicine, Imperial College London, June 11, 2012; Hosts: Dr. David Edward and Dr. Serena Counsell
White matter injury in the preterm infants: emerging insights from high field MRI

Department of Pediatrics, Division of Neonatal Medicine, University College London, June 12, 2012; Hosts; Dr. Nikki Robertson and Dr. Neil Marlow
“Brain injury in the premature infant: Unexpected mechanisms of dysmaturation, regeneration and repair”

MRC Centre for Stem Cell Biology and Regenerative Medicine, University of Cambridge, England, June 25, 2012
Hosts: Dr. Mark Kotter and Robin Franklin
“Brain injury in the premature infant: Unexpected mechanisms of dysmyelination, regeneration and repair”

Department of Anatomy, University of Oxford, England, June 29, 2012
Hosts: Dr. Franciz Szele and Zoltan Molnar
“Brain injury in the premature infant: Unexpected mechanisms of dysmaturation, regeneration and repair”

Department of Neurology, University of Rochester, New York, September 7, 2012
Neural Injury and Repair Seminar Series
“Brain injury in the premature infant: Unexpected mechanisms of dysmaturation, regeneration and repair”

Visiting Professor, University of Auckland School of Medicine, Auckland New Zealand
November 6-8, 2012
Clinical Lecture: “Brain injury in the premature infant: Unexpected mechanisms of dysmaturation, regeneration and repair”
Physiology Dept. Lecture: Cerebral injury in preterm fetal sheep:Unexpected mechanisms of dysmaturation, regeneration and repair”
Centre for Brain Research Lecture: White Matter Injury: Barriers to Regeneration and Repair.

Accolades

1989-1990 Postdoctoral research, laboratory of Dr. Howard L. Fields, Department of Neurology, University of California, San Francisco
1991-1992 Postdoctoral research fellow, Laboratory of Dr. James Fallon, Department of Anatomy and Neurobiology, University of California, Irvine
1990-1992 Resident in Pediatrics, University of California, Irvine
1995-1997 United Cerebral Palsy Foundation Clinical Fellowship, Department of Neurology, Children’s Hospital, Boston
1995-1999 NINDS Career Development Award, Laboratory of Dr. Joseph J. Volpe, Department of Neurology, Children’s Hospital, Boston, Harvard Medical School
Grass Foundation Morison Fellowship (1995-1996); Moore Award, Honorable Mention, American Association of Neuropathology (1999); Young Investigator Award, Child Neurology Society (2000); Ad hoc reviewer, NIH Study Section, Developmental Brain Disorders (2004-2009); MacKeith Basic Science Lectureship, American Academy of Cerebral Palsy (2005); Presidential Symposium Lecture, Child Neurology Society (2006); Javits Investigator Award, NINDS (2007); Clyde and Elda Munson Professorship in Pediatric Research at OHSU (2008); NINDS Stragegic Planning Working Group 1; Disease Module (2009); NINDS Stroke Progress Review Group, Neurocerebrovascular Degeneration (2011); NINDS Stroke Research Priorities Meeting, Prevention Workgroup (2012)

Alumni

Pediatrics, UCI, Neurology, Harvard Boston Children's Hospital
Professor of Pediatrics and Neurology, Clyde and Elda Munson Professor of Pediatric Research,
1989

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