Jennifer Schymick Profile Page
Jennifer Schymick

Profile

Jennifer
Schymick
...
Massachusetts Institute of Technology
B.S. Biology
University of Oxford
Ph.D. Clinical Medicine
2005

Research

Bryan Traynor, Andrew Singleton, John Hardy, Kay Davies, Kevin Talbot
The Genetics of Amyotrophic Lateral Sclerosis
Neuroscience
1. Schymick JC, Traynor BJ. Expanding the genetics of amyotrophic lateral sclerosis and frontotemporal dementia. Alzheimers Res Ther. 2012 Jul 26;4(4):30. Review. [Epub ahead of print]
2. Renton AE*, Majounie E*, Waite A*, Simón-Sánchez J*, Rollinson S*, Gibbs JR*, Schymick JC*, Laaksovirta H*, van Swieten JC*, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M; The ITALSGEN Consortium, Heckerman D, Rogaeva E, Zinman L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD. Neuron. 2011 Oct 20;72(2):257-68. Epub 2011 Sep 21.
3. Mok K, Traynor BJ, Schymick J, Tienari PJ, Laaksovirta H, Peuralinna T, Myllykangas L, Chiò A, Shatunov A, Boeve BF, Boxer AL, Dejesus-Hernandez M, Mackenzie IR, Waite A, Williams N, Morris HR, Simón-Sánchez J, van Swieten JC, Heutink P, Restagno G, Mora G, Morrison KE, Shaw PJ, Rollinson PS, Al-Chalabi A, Rademakers R, Pickering-Brown S, Orrell RW, Nalls MA, Hardy J. The chromosome 9 ALS and FTD locus is probably derived from a single founder.Neurobiol Aging. 2012 Jan;33(1):209.e3-8. Epub 2011 Sep 16.
4. Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, Arepalli S, Chong S, Schymick JC, Rothstein J, Landi F, Wang YD, Calvo A, Mora G, Sabatelli M, Monsurrò MR, Battistini S, Salvi F, Spataro R, Sola P, Borghero G; ITALSGEN Consortium, Galassi G, Scholz SW, Taylor JP, Restagno G, Chiò A, Traynor BJ. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 2010 Dec 9;68(5):857-64. Erratum in: Neuron. 2011 Jan 27;69(2):397.
5. Hannu Laaksovirta MD*, Terhi Peuralinna MSc*, Jennifer C. Schymick PhD*, Sonja W. Scholz MD, Shaoi-Lin Lai MD, Liisa Myllykangas MD, Raimo Sulkava MD, Lilja Jansson, Dena G. Hernandez MSc, J. Raphael Gibbs BS, Michael A. Nalls PhD, David Heckerman MD, Pentti J. Tienari MD, Bryan J. Traynor MD. Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. Lancet Neurology. Lancet Neurol. 2010 Oct;9(10):978-85. Epub 2010 Aug 27.
6. Chiò A, Calvo A, Moglia C, Restagno G, Ossola I, Brunetti M, Montuschi A, Cistaro A, Ticca A, Traynor BJ, Schymick JC, Mutani R, Marrosu MG, Murru MR, Borghero G. Amyotrophic lateral sclerosis - frontotemporal lobar dementia in three families with p.A382T TARDBP mutations. Archives of Neurology. Arch Neurol. 2010 Aug;67(8):1002-9.
7. Traynor BJ, Nalls M, Lai SL, Gibbs RJ, Schymick JC, Arepalli S, Hernandez D, van der Brug MP, Johnson JO, Dillman A, Cookson M, Moglia C, Calvo A, Restagno G, Mora G, Chiò A. Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12335-8. Epub 2010 Jun 21.
8. Lai SL, Abramzon Y, Schymick JC, Stephan DA, Dunckley T, Dillman A, Cookson M, Calvo A, Battistini S, Giannini F, Caponnetto C, Mancardi GL, Spataro R, Monsurro MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Lombardo F; the ITALSGEN Consortium, Mora G, Restagno G, Chiò A, Traynor BJ. FUS mutations in sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 2011 Mar;32(3):550.e1-4. Epub 2010 Feb 6.
9. Sha Q, Zhang Z, Schymick JC, Traynor BJ, Zhang S. Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis. BMC Med Genet. 2009 Sep 9;10:86.
10. Del Bo R, Corti S, Santoro D, Ghione I, Fenoglio C, Ghezzi S, Ranieri M, Galimberti D, Mancuso M, Siciliano G, Briani C, Murri L, Scarpini E, Schymick JC, Traynor BJ, Bresolin N, Comi GP. No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort. Neurobiol Aging. 2011 Jun;32(6):1157-8. Epub 2009 Jul 25.
11. Chiò A, Restagno G, Brunetti M, Ossola I, Calvo A, Mora G, Sabatelli M, Monsurrò MR, Battistini S, Mandrioli J, Salvi F, Spataro R, Schymick J, Traynor BJ, La Bella V; ITALSGEN Consortium. Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation. Neurobiol Aging. 2009 Aug;30(8):1272-5. Epub 2009 May 17.
12. Chiò A*, Schymick JC*, Restagno G*, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, Ding J, Crews C, Rafferty I, Washecka N, Hernandez D, Ferrucci L, Bandinelli S, Guralnik J, Macciardi F, Torri F, Lupoli S, Chanock SJ, Thomas G, Hunter DJ, Gieger C, Wichmann HE, Calvo A, Mutani R, Battistini S, Giannini F, Caponnetto C, Mancardi GL, La Bella V, Valentino F, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Siciliano G, Carlesi C, Orrell RW, Talbot K, Simmons Z, Connor J, Pioro EP, Dunkley T, Stephan DA, Kasperaviciute D, Fisher EM, Jabonka S, Sendtner M, Beck M, Bruijn L, Rothstein J, Schmidt S, Singleton A, Hardy J, Traynor BJ. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum Mol Genet. 2009 Apr 15;18(8):1524-32. Epub 2009 Feb 4.
13. Guerreiro RJ, Schymick JC, Crews C, Singleton A, Hardy J, Traynor BJ. TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis. PLoS ONE. 2008 Jun 11;3(6):e2450.
14. Jakobsson M, Scholz SW, Scheet P, Gibbs JR, VanLiere JM, Fung HC, Szpiech ZA, Degnan JH, Wang K, Guerreiro R, Bras JM, Schymick JC, Hernandez DG, Traynor BJ, Simon-Sanchez J, Matarin M, Britton A, van de Leemput J, Rafferty I, Bucan M, Cann HM, Hardy JA, Rosenberg NA, Singleton AB. Genotype, haplotype and copy-number variation in worldwide human populations. Nature. 2008 Feb 21;451(7181):998-1003.
15. van Es MA, van Vught PW, Blauw HM, Franke L, Saris CG, Van den Bosch L, de Jong SW, de Jong V, Baas F, van't Slot R, Lemmens R, Schelhaas HJ, Birve A, Sleegers K, Van Broeckhoven C, Schymick JC, Traynor BJ, Wokke JH, Wijmenga C, Robberecht W, Andersen PM, Veldink JH, Ophoff RA, van den Berg LH. Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nat Genet. 2008 Jan;40(1):29-31. Epub 2007 Dec 16.
16. Cronin S, Berger S, Ding J, Schymick JC, Washecka N, Hernandez DG, Greenway MJ, Bradley DG, Traynor BJ, Hardiman O. A genome-wide association study of sporadic ALS in a homogenous Irish population. Hum Mol Genet. 2008 Mar 1;17(5):768-74. Epub 2007 Dec 5.
17. Schymick JC, Talbot K, Traynor BJ. Genetics of sporadic amyotrophic lateral sclerosis. Hum Mol Genet. 2007 Oct 15;16 Spec No 2:R233-42. Review.
18. Schymick J, Yang Y, Andersen P, Vonsattel J, Greenway M, Momeni P, Elder J, Chio A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli R, Hutton M, Gass J, Cannon A, Rademakers R, Singleton A, Hardiman O, Rothstein J, Hardy J, Traynor B. Progranulin mutations and ALS or ALS-FTD phenotypes. J Neurol Neurosurg Psychiatry. 2007 Jul;78(7):754-6. Epub 2007 Mar 19.
19. Schymick JC, Scholz SW, Fung HC, Britton A, Arepalli S, Gibbs JR, Lombardo F, Matarin M, Kasperaviciute D, Hernandez DG, Crews C, Bruijn L, Rothstein J, Mora G, Restagno G, Chiò A, Singleton A, Hardy J, Traynor BJ. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol. 2007 Apr;6(4):322-8.
20. Momeni P*, Schymick J*, Jain S*, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chiò A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, Hutton ML, Rogaeva E, St George-Hyslop P, Rothstein JD, Hardiman O, Grafman J, Singleton A, Hardy J, Traynor BJ. Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. BMC Neurol. 2006 Dec 13;6:44.
21. Fung HC, Scholz S, Matarin M, Simón-Sánchez J, Hernandez D, Britton A, Gibbs JR, Langefeld C, Stiegert ML, Schymick J, Okun MS, Mandel RJ, Fernandez HH, Foote KD, Rodríguez RL, Peckham E, De Vrieze FW, Gwinn-Hardy K, Hardy JA, Singleton A. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol. 2006 Nov;5(11):911-6.
Oral Presentations:
1. Genetics of Amyotrophic Lateral Sclerosis. University of California Irvine 14th Annual MSTP Retreat. Lake Arrowhead, CA. October 24, 2009.
2. Genome-wide Studies in Amyotrophic Lateral Sclerosis. 2008 NIH Oxford Cambridge Program Colloquium. Bethesda, MD. June 19, 2008.
3. A Genome-wide Association Study of Amyotrophic Lateral Sclerosis. American Academy of Neurology Annual Meeting. Boston, MA. May 2, 2007. [S40.004]
4. Public Release of Data. Genome-wide Association Studies in ALS Meeting. National Institutes of Health, Rockville, MD. April, 2007.
5. Vivo@MIT. Society for Adolescent Medicine. Boston, MA. 2002.

Posters:
1. D. Heckerman, C. Kadie, X. Zhang, J. Schymick, J. Ravits, B. Traynor, J. Listgarten. A Natural Aggregation Function for Pathway/Network-Based Approaches to GWAS and Gene Expression Analysis. American Society of Human Genetics Annual Meeting, Honolulu, Hawaii, Oct 22. 2009. 1707/T/Poster Board 256.
2. S. Lai, Y. Abramzony, J. C. Schymick, R. Guerreiro, D. A. Stephan, G. Mora, G. Restagno, A. Chiò, B. J. Traynor on behalf of The ITALSGEN Consortium. FUS mutations are a rare cause of sporadic amyotrophic lateral sclerosis. American Society of Human Genetics Annual Meeting, Honolulu, Hawaii, Oct 22. 2009. 2088/T/Poster Board 637.
3. Schymick J, et al. Two-stage genome-wide Association Study in Amyotrophic Lateral Sclerosis. Medical Science Training Program Annual MD/PhD Student Conference. University of Colorado, Keystone, CO, July, 2009.
4. Schymick J, et al. Two-stage genome-wide Association Study in Amyotrophic Lateral Sclerosis. Scholars in Biomedical Sciences Research Colloquium. Oxford, UK. June, 2009.
5. B. J. Traynor, A. Chio, J. C. Schymick, G. Restagno, S. Lai, G. Mora, L. Ferrucci, F. Macciardi, S. J. Chanock, C. Gieger, H. E. Wichmann, J. Connor, T. Dunkley, D. A. Stephan, M. Sendtner, M. Beck, L. Bruijn, J. Rothstein, A. Singleton, J. Hardy. Genome-wide association study of amyotrophic lateral sclerosis identifies multiple loci. American Society of Human Genetics Annual Meeting, Philadelphia, Nov 14. 2008. 1909/F.
6. Schymick J, et al. Genome-wide Association Study in Amyotrophic Lateral Sclerosis. Scholars in Biomedical Sciences Research Colloquium. Cambridge, UK. July, 2007.
7. Schymick J, Hardy J, Traynor B. Genetics of ALS-FTD. American Academy of Neurology Annual Meeting. Boston, MA, May 3, 2007. [P07.076]
8. Schymick J, et al. Genome-wide Association Study in Amyotrophic Lateral Sclerosis. Fourth Annual NIH Graduate Student Research Symposium. National Institutes of Health, Bethesda, MD. June, 2007.
9. Schymick J, Traynor B, Hardy J. Genome-wide Association of Sporadic ALS Using the 550K SNP Illumina BeadChip Platform. Scholars in Biomedical Sciences Research Colloquium. Oxford, UK. June, 2006.
10. Vo T, Schymick J, Marucut J, Kammeshedit A. Comprehensive Gene Sequence Analysis from Bloodspot and Saliva DNA. Ambry Genetics, Irvine, CA. November, 2005.
11. Terry A, Aerts A, Bondoc M, Brower A, Chen B, Kadner K, Frankel K, Mundt M, Nolan M, Pitluck S, Predki P, Schymick J, Wu JR, Olsen A, Hawkins T, Branscomb E. Order and Orientation: Adding Value to the Draft Sequence of Human Chromosomes 5, 16 & 19. 12th International Genome Sequencing and Analysis Conference, Miami, FL, 2000.
12. Schymick J. Using Bioinformatics to Finish Draft Sequence of Human Chromosome 16. Los Alamos National Laboratory. Los Alamos, NM. August, 2000.

Published abstracts:
1. Moglia C, Calvo A, Lai SL, Abramzon Y, Schymick JC, Guerreiro RJ, Stephan DA, Dunckley T, Mutani R, Mora G, Gallo S, Giannini F, Battistini S, Salvi F, Bartolomei I, Carlesi C, Siciliano G, Mandrioli J, Sola P, Caponnetto C, Mancardi G, Marinou K, Brunetti M, Conte A, Sabatelli M, Valentino F, La Bella V, Tedeschi G, Monsurro MR, Restagno G, Traynor BJ, Chio A. FUS Mutations in a Large Series of Sporadic and Familial ALS. Neurology. Mar 2010. 74:9; pp. A334–A334. Lippincott Williams & Wilkins.
2. Lai S-L, Abramzony YG, Dunckley T, Stephan DA, Battastini S, La Bella V, Salvi F, Mandrioli J, Caponnetto C, Siciliano G, Monsurro MR, Mora G, Sabatelli M, Brunetti M, Schymick JC, Traynor BJ, Restagno G, Chio A. FUS mutations in a large series of sporadic and familial ALS. Amyotrophic Lateral Sclerosis. 2009 (Suppl. 1);10: 36-37.

Alumni

Internal Medicine
University of Toronto, Canada
Toronto, Canada
2013

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